Is now the time for molecular driven therapy for diffuse large B-cell lymphoma?

INTRODUCTION: Recent genetic and molecular discoveries regarding alterations in diffuse large B-cell lymphoma (DLBCL) deeply changed the approach to this lymphoproliferative disorder. Novel additional predictors of outcomes and new therapeutic strategies are being introduced to improve outcomes. Areas covered: This review aims to analyse the recent molecular discoveries in DLBCL, the rationale of novel molecular driven treatments and their impact on DLBCL prognosis, especially in ABC-DLBCL and High Grade B Cell Lymphoma. Pre-clinical and clinical evidences are reviewed to critically evaluate the novel DLBCL management strategies. Expert commentary: New insights in DLBCL molecular characteristics should guide the therapeutic approach; the results of the current studies which are investigating safety and efficacy of novel 'X-RCHOP' will probably lead, in future, to a cell of origin (COO) based upfront therapy. Moreover, it is necessary to identify early patients with DLBCL who carried MYC, BCL2 and/or BCL6 rearrangements double hit lymphomas (DHL) because they should not receive standard R-CHOP but high intensity treatment as reported in many retrospective studies. New prospective trials are needed to investigate the more appropriate treatment of DHL

Optimal Management of a Diesel-Electric Propulsion Plant with Either Constant or Variable Diesel Generators Speed

In recent years, diesel-electric propulsion has become a standard for many ship types. The traditional way to manage the electric flow onboard is by using AC distribution, and to run diesel generators at constant rotational speed to get the correct distribution frequency and to limit the weight and the size of the electric machinery. More recently, the current progress in DC field allowed exploiting the advantages of this technology, for instance, greater flexibility in the mode of operation of diesel generators in terms of rotational speed, with benefits in terms of efficiency. In this article, a pleasure craft, originally powered with a traditional propulsion plant, is repowered with two alternative diesel-electric propulsion plant layouts: a standard one, with AC distribution and torque controlled diesel generators at a constant speed, and a DC-link one with variable speed controlled generators. Variable speed diesel generators require a custom control system to manage the additional degree of freedom involved. For such a reason, the optimal working points of the diesel engines are assessed in design and off-design conditions by using a genetic algorithm, with the final aim of minimising the overall fuel consumption rate. The performance of the two analysed propulsion plants are evaluated and compared at different power levels. Eventually, the results are presented and discussed

Desarrollo embrionario del cangrejo nadador Ovalipes trimaculatus (Decapoda: Brachyura: Portunoidea)

The embryogenesis of Ovalipes trimaculatus, a member of the highly valued portunid swimming crabs, was studied under nearly constant temperature (13±1°C), salinity (33) and photoperiod (14 h light:10 h dark) conditions. A five-stage scale of embryonic development was defined for the species. Time required to complete development averaged 35.7±2.11 days, showing no significant differences between embryos located in inner, middle and outer portions of the egg mass. The egg chorion was rounded and showed the highest growth in diameter between stages I (morula-blastula-gastrula) and II (primordium of larval structure) and between stages III (appendage formation) and IV (eye formation). Results reported here provide a baseline for optimizing hatchery operations and useful information for management purposes.Se estudió la embriogénesis del cangrejo nadador Ovalipes trimaculatus, miembro de la familia de portúnidos altamente valorados, bajo condiciones constantes de temperatura (13±1°C), salinidad (33) y fotoperíodo (luz 14h:10h oscuridad). Se definió una escala de cinco etapas de desarrollo embrionario para la especie. El tiempo necesario para completar el desarrollo es de 35.7±2.11 días, sin mostrar diferencias significativas entre embriones ubicados en porciones interior, media y exterior de la masa de huevos. Los huevos son esféricos y presentan mayor crecimiento en diámetro entre las etapas I (mórula - blástula - gástrula) y II (primordio de estructuras larvarias) y entre las etapas III (formación de apéndices) y IV (formación de los ojos). Los resultados aquí presentados proporcionan la base para la optimización del cultivo y brindan información útil para el manejo de la especie